| abstract |
The present invention is directed to the analogous compounds of Buprenorphine of Formula I, Formula lA or Formula IB which are taught below, in which R1, R2, R8, R3a, R3b, G, X, Z and Y are as They have defined in the description. (See Formulas) The compounds of the invention are useful for treating pain, constipation, and other conditions modulated by the activity of opioid and ORL-1 receptors. |