| abstract |
To find a therapeutic and / or prophylactic agent for gastrointestinal disorders and the like, the agent that has excellent activity and high safety. A compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof. In the formula, A represents an optionally substituted phenylene group; B represents an optionally substituted 4 to 10 membered heterocyclic group, an optionally substituted 6 to 10 carbon aryl group or an optionally substituted 3 to 10 carbon atoms cycloalkyl group; R1 represents a hydrogen atom or an alkyl group of 1 to 3 carbon atoms; R2 represents a hydrogen atom or an alkyl group of 1 to 3 carbon atoms; R3 represents an alkyl group of 1 to 6 carbon atoms, a cycloalkyl group of 3 to 10 carbon atoms, an alkoxy (1 to 3 carbon atoms) -alkyl group of 1 to 3 carbon atoms or a hydroxyalkyl group of 1 to 3 carbon atoms; R4 represents a hydrogen atom, an alkyl group of 1 to 6 carbon atoms or a halogen atom; n represents an integer from 1 to 4; and X represents methylene, -O-; -NH-, -N (alkyl of 1 to 3 carbon atoms) -, -C = O-, -S-, -SO -, - SO2- or a single bond. (see Formula). |