abstract |
The present invention provides an antibody of the IgG4 class comprising at least one heavy chain which comprises a CH1 domain and a hinge region, wherein in each heavy chain: a. the cysteine interchain at position 127, numbered according to the Kabat numbering system, in the CH1 domain is substituted with another amino acid; and b. One or more of the amino acids placed in the upper hinge region is substituted with cysteine. |