| abstract |
Picolinamide and pyrimidin-4-carboxyamide compounds, a method for preparing them, a pharmaceutical composition containing the same, and a medical use using the compound as an agent to prevent, regulate, and treat diseases related to it are provided. regulation of glucocorticoids using selective inhibitory activity of the compound for an 11β-HSDl enzyme. The picolinamide and pyrimidin-4-carboxamide compounds of the present invention are selective inhibitors of human-derived enzymes 11β-HSD1, and are useful in an agent for preventing, regulating, and treating diseases related to glucocorticoid regulation in which they are Engaged enzymes derived from human 11β-HSDl, for example, metabolic syndromes such as, type 1 and type 2 diabetes, subsequent complications of diabetes, latent autoimmune diabetes in adults (LADA), insulin tolerance syndromes, obesity, impaired glucose tolerance (IGT), impaired fasting glucose (IFG), impaired glucose tolerance, dyslipidemia, atherosclerosis, hypertension, etc. |