| abstract |
The present invention relates to new kinase inhibitors, more specifically ROCK inhibitors, to compositions, in particular to pharmaceutical compositions, comprising said inhibitors and to the uses of those inhibitors in the treatment and prophylaxis of diseases. In particular, the present invention relates to new ROCK inhibitors, with compositions, in particular pharmaceutical compositions, comprising those inhibitors, and to the uses of those inhibitors in the treatment and prophylaxis of diseases. In addition, the invention relates to methods of treatment and the use of said compounds in the manufacture of a medicament for application to various therapeutic indications, including: sexual dysfunction, inflammatory diseases, ophthalmic diseases and respiratory diseases. |