http://rdf.ncbi.nlm.nih.gov/pubchem/patent/MX-2012009920-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fe3f2d4f405df889e4d23b14700ba764 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-00 |
| filingDate | 2012-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0c66f38368ca51f8062b0a8da4d6377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_030863225a06acd7807f1878a1fbab13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c7b1cf5a1605a9b189a5f37b5a61d8bb |
| publicationDate | 2014-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | MX-2012009920-A |
| titleOfInvention | PROCESS FOR OBTAINING THE ENANTIOMERS OF PRAZIQUANTEL AND ITS 4ยด-HYDROXYLATE DERIVATIVES. |
| abstract | The present invention provides a new process for the easy and economical obtaining of (R) - (-) - praziquantel, (S) - (+) - praziquantel, as well as a process for the synthesis of its main hydroxylated metabolites. The process of the present invention involves the resolution of praziquanamine 12,3,6,7,11b-hexahydro-4H-pyrazino [2,1-a] isoquinolin-4-one, with (S) - (+) - naproxen as a resolution agent; while the synthesis of cis and trans-4'-hydroxylated stereoisomers of (R) - (-) - praziquantel is carried out from the mixture cis and trans-4'-hydroxycyclohexanecarboxylate ethyl and (R) - (- ) -praziquanamine. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105061424-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105753865-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107151246-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107151246-A |
| priorityDate | 2012-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 94.