| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b4f608e347e1db332bbede1119562c01 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-73
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-28 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
| filingDate |
2011-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f9e3b2ea0e5c84c536b7fa2a7e98431f |
| publicationDate |
2012-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
MX-2012008085-A |
| titleOfInvention |
UNION NOTCH1 AGENTS AND METHODS OF USE OF THE SAME. |
| abstract |
The present invention relates to Notch1 binding agents and methods for using agents to treat diseases, such as hematological cancers. The present invention provides antibodies that specifically bind to a proximal membrane region not bound to the ligand of the human Notch1 extracellular domain. The present invention further provides methods for using agents that inhibit the activity of Noth1 to treat cancer. Methods for treating hematological cancers are also described which comprise administering a therapeutically effective amount of a binding agent or antibody of the present invention to a subject suffering from hematologic cancer, such as lymphoblastic T-cell leukemia. |
| priorityDate |
2010-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |