| abstract |
The present invention aims to provide means for conveniently and effectively treating diseases where corneal endothelial cells deficient in proliferative capacity in vivo are damaged; The present invention provides a therapeutic agent for endothelial dysfunction of the cornea containing (R) - (+) - N- (1 H -pyrrolo [2,3- b] pyridin-4-iI) -4- (1-aminoethyl) ) benzamide <Y-39983> or a pharmacologically acceptable salt thereof (compound (la)) as an active ingredient, an agent to promote the adhesion of endothelial cells of the cornea, which contains the compound (la), a culture medium for endothelial cells of the cornea, which contains the agent to promote adhesion, an implant for endothelial keratoplasty of the cornea, which contains endothelial cells of the cornea, a scaffold and the compound (la), and a method of producing a preparation Endothelial cornea, including a step of culturing corneal endothelial cells using the culture medium. |