| abstract |
There are methods in the art for detecting simple peptides; however, the methods for determining the effective plasma concentration of directed sequence polymers (DSPS) are complicated because DSPS are complex mixtures of peptides, as opposed to individual peptides with a defined amino acid sequence; This application provides improved methods for detecting and evaluating DSP compositions, methods for the detection and quantification of DSP compositions, means for determining and enriching a subset of peptides in a DSP composition based on subgroup interactions with certain capture polypeptides. , and methods for administering DSP compositions to a subject in need thereof, wherein the regimen and dosage amount can be determined or evaluated based on the methods mentioned above for detection and quantification. |