| abstract |
This invention describes analogs 1-deoxy-2-methylene-19-nor-vitamin to D and specifically (20S) -25-hydroxy-1-deoxy-2-methylene-19-nor-vitamin D3 and pharmaceutical uses therefor. This compound exhibits relatively high binding activity and pronounced activity in the arrest of the proliferation of undifferentiated cells and the induction of their differentiation to the monocyte, thus proving the use as an anticancer agent especially for the treatment or prevention of leukemia, cancer of colon, breast cancer, skin cancer or prostate cancer. |