| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6d5570a1e130a06ceff2cf50be82ba83 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-567
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-522 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39591 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00 |
| filingDate |
2010-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9ffb561db2572366d97bf7ca341cdc4c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_99e24aa129a6a062be129336e3fff775
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa7a93f33d32a763b92b04d7ea6eec31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe22a75dea984e94e2a35f48f906ec45
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a7f5ddfbaae1ea8699b727ff3076a34b |
| publicationDate |
2012-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
MX-2012002100-A |
| titleOfInvention |
VARIABLE IMMUNOGLOBULINS WITH IMPROVED MANUFACTURING. |
| abstract |
The invention relates to the modification of the amino acid sequences of an immunoglobulin molecule at certain key positions within regions of the FR and CDR3 domains of VH and VL and / or the CH1 domain that are prone to aggregation. Modified immunoglobulins as described may show improved production, for example, reduced propensity to aggregation and / or increased production levels. |
| priorityDate |
2009-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |