| abstract |
The present application provides compositions comprising hyaluronic acid having low levels of functional group modification, mixtures formed by the controlled reaction of this slightly modified hyaluronic acid with suitable difunctional or multifunctional crosslinkers, and hydrogel precursor compositions and the resulting hydrogels. The compositions are slightly crosslinked and have few pro-inflammatory properties when injected in vivo, and can be used as, for example, medical devices, sealants and biomedical adhesives, and for localized administration of bioactive agents, among other uses. |