abstract |
It is intended to provide a novel azabicyclo compound which exhibits HSP90 inhibitory activity and cell proliferation inhibitory effect; specifically described, it is a compound represented by the following general formula (I), or a salt thereof: (see formula (I)) wherein X1 represents CH or N; any of X2, X3 and X4 represents N, and the others represent CH; Either one or two of Y1, Y2, Y3 and Y4 represents C-R4, and the others are the same or different, and represent CH or N; R1 represents an optionally substituted monocyclic or bicyclic unsaturated heterocyclic group having 1 to 4 heteroatoms selected from N, S and O; R2 represents an alkyl group having 1 to 6 carbon atoms, or the like; and R3 and R4 represent -CO-R5, or the like. |