| abstract |
The present invention relates to amino acid sequences that are directed against and / or that can specifically bind to the interleukin-6 receptor (IL-6R) with improved affinity and / or greediness, and / or that has an efficacy and / or potency enhanced, and that are capable of (partially, or preferably completely) blocking the IL-6 / IL-6R interaction and / or inhibiting signaling through IL-6, IL-6R and / or the IL-6 complex / IL-6R. The invention further relates to compounds or structures, and in particular proteins and polypeptides that comprise or consist essentially of one or more of these amino acid sequences. The invention also relates to nucleic acids encoding amino acid and polypeptide sequences, with methods for preparing these amino acid and polypeptide sequences, with host cells that express or are capable of expressing these amino acid or polypeptide sequences, with compositions, and in particular with pharmaceutical compositions comprising these amino acid, polypeptide, nucleic acid and / or host cell sequences and with the uses of these amino acid or polypeptide sequences, nucleic acids, host cells and / or compositions, in particular for prophylactic, therapeutic purposes. or diagnostic |