| abstract |
In one aspect, the present invention provides a compound of Formula (I) in which, the variables X1, X2a X2b, X2C, R1, B, L, E, A and the subscript n are as defined herein. In another aspect, the present invention provides pharmaceutical compositions comprising compounds of Formula (I) as well as methods for using compounds of Formula (I) for the treatment of diseases and conditions (eg, cancer, thrombocythemia, etc.) characterized by the expression or overexpression of anti-apoptotic proteins Bc1-2, eg, of anti-apoptotic proteins BC1-xL. |