| abstract |
The invention provides compositions and methods for inhibiting the fractionation of immunoglobulins comprising a lambda light chain based on the observation that iron, in the presence of histidine, results in increasing fractionation of a recombinant completely human lgG molecule that contains a light chain. lambda due to segmentation in the hinge region. The invention further provides an aqueous pharmaceutical formulation comprising an antibody, or antigen-binding portion thereof, that binds the p40 subunit of IL-12 / IL-23 and a buffer system comprising histidine, wherein the formulation has a stability. enhanced, which includes improved resistance to fragmentation. |