| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_96b882006e755dfc56fcabfc5fb019f6 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-416
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4155
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 |
| filingDate |
2009-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8848e6320f8366c52d16520c027ccbc5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_edaa98532832c887c8e4d8dae8f4a304
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_97c52bc7859a8b5d48083fef9cc6f872
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76ddaddb1bdd36c728ab4cd26607ede2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ebc83468f61705c461a292c3edbd6ec9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_54dd4ae649c5528c691acf4ffec2c6eb |
| publicationDate |
2011-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
MX-2011005577-A |
| titleOfInvention |
CARBONIC ACID DERIVATIVES SUBSTITUTED WITH PIRAZOLIL AS MODULATORS OF THE PROSTACICLINE RECEIVER (PGI2) USEFUL FOR THE TREATMENT OF DISORDERS RELATED TO THESE. |
| abstract |
Pyrazole derivatives of Formula la and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor are described. The compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of pulmonary arterial hypertension (PAH) and related disorders; platelet aggregation; coronary artery disease; myocardial infarction; transient ischemic attack; angina; apoplexy; ischemia reperfusion damage; restenosis; atrial fibrillation; formation of blood clots in an angioplasty or coronary artery bypass surgery or in an individual suffering from atrial fibrillation; atherosclerosis; atherothrombosis; asthma or a symptom of it; a diabetes-related disorder such as diabetic peripheral neuropathy, diabetic nephropathy or diabetic retinopathy; glaucoma or other eye disease with abnormal intraocular pressure; hypertension; psoriasis inflammation; psoriatic arthritis; rheumatoid arthritis; Crohn's disease; transplant rejection; multiple sclerosis; systemic lupus erythematosus (SLE); Ulcerative colitis; ischemia reperfusion damage; restenosis; atherosclerosis; type 1 diabetes acne; type 2 diabetes; sepsis; and chronic obstructive pulmonary disorder (COPD). |
| priorityDate |
2008-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |