| abstract |
The present invention relates to novel phenyl oxazolidinone compounds of the formula I, their pharmaceutically acceptable derivatives, tautomeric forms, stereoisomers, including R and S isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of the novel compounds of the formula I or their pharmaceutically acceptable derivatives, tautomeric forms, stereoisomers, including R and S isomers, polymorphs, prodrugs, metabolites, salts or solvates of the same. The present invention also provides pharmaceutical compositions comprising the novel compounds of the formula I and the methods for using them. The compounds of the present invention are useful as antimicrobial agents, effective against various aerobic Gram-positive and / or anaerobic Gram-negative pathogens as multi-drug resistant species of Staphylococcus, Streptococcus, Enterococcus, Bacterioid, Clostridia, H. influenza , Moraxella, acid-resistant organisms such as Mycobacterium tuberculosis as well as species resistant to Linezolid of Staphylococcus and Enterococcus. |