| abstract |
The present invention relates to new therapeutic agents and diagnostic probes. The invention also relates to phosphoinositide 3-kinase (PI3K) and compounds based on triazine, pyrimidine. and pyridine inhibitors of the mammalian target of rapamycin (mTOR) of the formula (I), its stereoisomers, geometric isomers, tautomers, solvates, metabolites, N-oxide derivatives, pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, to treat disorders mediated by lipid kinases. Methods for using compounds of the formula (I) for diagnosis, prevention or in vitro, in situ, and in vivo treatment of such disorders in mammalian cells, or associated pathological conditions are described. |