| abstract |
The present invention relates to novel compounds of formula I and therapeutically acceptable salts thereof, their pharmaceutical compositions, processes for preparing them and their use in therapeutic methods for the treatment and / or prevention of various diseases. In particular, the invention relates to compounds that inhibit the production of Aß40 and Aß42, increase the production of Aß37 and Aß38 and maintain Notch signaling and will be used for the treatment and / or prevention of pathologies related to Aß, such as Alzheimer's disease, Down syndrome and ß-amyloid angiopathy, such as, without limitation, cerebral amyloid angiopathy, hereditary cerebral hemorrhage, disorders associated with cognitive impairment, such as, without limitation, DCL ("cognitive impairment mild "), Alzheimer's disease, memory loss, symptoms of attention deficit associated with Alzheimer's disease, neurodegeneration diseases such as Alzheimer's disease or dementia, including dementia of mixed and degenerative vascular origin, presenile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or short degeneration icobasal. |