| abstract |
The present invention relates to new radiolabeled inhibitors of the general formula I for the glycine 1 (G1 and T1) transporter, useful for marking and imaging for diagnostic purposes of the functionality of the glycine 1 transporter (see formula ( I)) in which R1 is isopropoxy or 2,2,2-trifluor-1-methyl-ethoxy; and R2 is a radiolabeled CH3 group, in which the radionuclide is H3 or C11. It has been found that the radiolabeled compounds of the formula I can be used as radiotracers Positron Emission Tomography (PET) for labeling and the generation of molecular images for diagnostic purposes of the functionality of the glycine transporter 1. |