| abstract |
Methods are provided for the treatment of a condition or disease mediated by the TSLP or TSLPR, which comprises the administration of an electrokinetically altered aqueous fluid comprising an ionic aqueous solution of nanostructures containing oxygen stabilized by load, which have a substantially smaller average diameter. of approximately 100 nanometers and which are stably configured in the ionic aqueous fluid in an amount sufficient to treat a condition or disease mediated by the TSLP or TSLPR. Nanostructures containing charge stabilized oxygen are preferably stably configured in the fluid in an amount sufficient to provide modulation of the cell membrane's potential and / or conductivity. Some aspects that comprise the down-modulation or regulation of the expression and / or activity of TSLP are useful for treating diseases or conditions mediated by the TSLP or mediated by TSLPR, as described herein (for example, immune system disorders, allergic inflammation, allergic inflammation of the respiratory tract, Th2-mediated inflammatory responses by DC, atopic dermatitis, atopic eczema, asthma, obstructive airways disease, chronic obstructive pulmonary disease, and food allergies, inflammatory arthritis, rheumatoid arthritis, psoriasis, IgE-mediated disorders, and rhino-conjunctivitis.). |