| abstract |
Methods for the isolation and purification of antibodies are described herein where the use of an affinity chromatographic step results in an antibody composition pure enough for pharmaceutical uses. The methods described herein comprise viral reduction / deactivation by pH, ultrafiltration / diafiltration, affinity chromatography, preferably protein A affinity chromatography, ion exchange chromatography, and hydrophobic chromatography. In addition, the present invention is directed towards pharmaceutical compositions comprising one or more antibodies of the present invention. |