| abstract |
The present invention relates to the new idebenone derivatives substituted with carboxylic acid, to the skin treatment compositions containing these idebenone derivatives substituted with carboxylic acid, the methods of treating skin changes by topical application of these idebenone derivatives substituted with carboxylic acid, and their methods of synthesis. The idebenone derivatives substituted with carboxylic acid of the present invention are unexpectedly effective in the treatment of the skin, particularly with respect to skin tolerance. When included in a topical composition, the carboxylic acid-substituted idebenone derivatives of the present invention have an antioxidant effect that is useful in the treatment of a skin change. |