| abstract |
The present invention provides compounds of formula (I) or (la), which are HDM2 protein binding ligands, which induce apoptosis and proliferation inhibition, and which have therapeutic utility in the treatment and prevention of cancer. The compounds of formula (I) or (Ia) can be used as therapeutic materials for the treatment of stroke, myocardial infarction, ischemia, multiorganic insufficiency, spinal cord injury, Alzheimer's disease, ischemic event injuries and degenerative disease cardiac valve On the other hand, the compounds of the formula (I) (See Formula (I)) or (the) (See formula (Ia)) can be used to decrease the side effects of cytotoxic agents for cancer, radiation and for Treat viral infections |