| abstract |
Compounds of the formula I are described, including their stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts, which are useful in modulating the signaling of PIKK-related kinases, for example, mTOR and for the treatment of diseases (for example, cancer) that are mediated at least in part by deregulation of the PIKK signaling pathway (for example, mTOR). (see formula (I)). |