| abstract |
The present invention relates to a compound of the following general formula (I): R1 -NH-CH (R2) -P (= O) (OR3) -CH2-C (R4) (R5) -CONH-C H ( R6) -COOR7 (I) or a pharmaceutically acceptable salt thereof, an isomer or a mixture of isomers in all proportions, notably a mixture of enantiomers, and in particular, a racemic mixture, for which R1 represents a group -C ( = O) -OC (R8) (R9) -OC (= O) -R10; R2 represents an optionally substituted hydrocarbon chain, an aryl or heteroaryl group or a methylene group substituted by a heterocycle; R3 represents a hydrogen atom or a group-C (R12) (R13) -OC (= O) -R14; R4 and R5 together with the carbon that carries them, a saturated hydrocarbon ring or an optionally substituted piperidine ring or R4 represents a hydrogen atom and R5 represents an optionally substituted phenyl or benzyl, a heteroaromatic ring or a methylene group substituted by a heterocycle; R6 represents an optionally substituted hydrocarbon chain or an optionally substituted phenyl or benzyl; and R7 represents a hydrogen atom or a benzyl, alkyl, heteroaryl, alkylheteroaryl, -CHMe-COOR18, -CHR19-OC (= O) R20 and -CHR19-OC (= O) OR20 group. The present invention also relates to the use of these compounds as a medicament, and in particular for the treatment of pain, more advantageously neuropathic and neuroinflammatory pain, their method of synthesis as well as the compositions containing them. |