| abstract |
The present invention provides a family of non-naturally occurring polypeptides that have cholesterol efflux activity that is parallel to that of full-length apolipoproteins (eg, apo Al and apo E) and that have high selectivity for ABAC1 that It is parallel to that of the full-length apolipoproteins. The invention also provides compositions comprising such polypeptides, methods for identifying, selecting and synthesizing such polypeptides and methods for the treatment, prevention or diagnosis of diseases and disorders associated with dyslipidemia, hypercholesterolemia and inflammation. |