| abstract |
The present invention relates to pyrazoloquinazolines, characterized by an orthosubstituted arylamino, heterocyclylamino or C3-C7 cycloalkylamino residue at position 8, and a C3-C7 aryl, heterocyclyl or cycloalkyl as a substituent of a carboxamide at position 3 of the backbone of the molecule The compounds of this invention modulate the activity of protein kinases, and therefore are useful for treating diseases caused by a deregulated protein kinase activity, in particular MPS1 / TTK. The present invention also provides methods for preparing these compounds, fannaceutical compositions comprising these compounds, and methods for treating diseases using pharmaceutical compositions comprising these compounds. |