| abstract |
A glucocorticoid receptor agonist consisting of a compound represented by the formula (1) or a salt thereof is disclosed, which is a derivative of 2,2,4-trimethyl-6-feriyl-1,2-d-hydroquinoline which It has a substituted oxy group. A novel pharmacological action of the agonist is also disclosed. In the formula, R1 represents a group represented by the formula (2a), (3a), (4a) or (5a); R2 represents - (CO) -R8, - (CO) O-R9 or the like; R2-O- is substituted at position 4 or position 5 of benzene ring A; R3 represents a lower alkyl group; R4, R5, R6 or R7 represents a halogen atom, an optionally substituted lower alkyl group or the like; m, n, p or q represents 0, 1 or the like; and R8, R9 or the like represents an optionally substituted lower alkyl group, a lower alkenyl group or the like. |