| abstract |
The present invention relates to a process for preparing a powder comprising the steps of providing at least a first component that is in liquid form at room temperature, which in particular has a viscous liquid consistency, such as an oil; or having a waxy consistency at room temperature, in particular a component which is a solid or semi-solid at room temperature and having a melting start in the temperature range of 15 ° C to 40 ° C, providing at least a second component having a melting temperature or melting range in the range of about room temperature to below the degradation temperature of the first component, in particular in the range of above room temperature to 120 ° C, so more particularly in the range of> 40 ° C to 120 ° C, even more particularly in the range of 50 ° C to 120 ° C, even more particularly in the range of 55 ° C to 120 ° C, form a homogeneous liquid mixture comprising at least a first component and at least a second component by stirring and heating the mixture at or maintaining the mixture at a temperature in the range above the melting temperature not the melting range of the second component and below the degradation temperature of the first component, in particular in the range above the melting temperature or melting range of the second component up to 120 ° C, transfer the liquid mixture to at least a spray freezing unit by at least one transfer unit, which is adapted to keep the mixture in its liquid form during its transfer, freeze the mixture by dew, and isolate the dust obtained after spray freezing. Furthermore, the present invention relates to a process for the preparation of a solid dosage form comprising the powder resulting from the previous process. |