| abstract |
The invention provides compositions, vaccine compositions and pharmaceutical compositions for the treatment, amelioration and / or prevention of dengue fever. The compositions, vaccine compositions and pharmaceutical compositions of the invention comprise a virus-like particle of an RNA bacteriophage and at least one antigen, wherein at least one antigen is a dengue antigen. When administered to an animal, preferably a human, the compositions, vaccine compositions and pharmaceutical compositions induce efficient immune responses, in particular antibody responses, where typically and preferably antibody responses are directed against the dengue virus, preferably against dengue virus of any of serotypes 1 to 4. Thus, the invention additionally provides methods for treating, improving and / or preventing dengue virus infection by means of active immunization against protein domain III. E of dengue virus envelope, or against antigenic fragments thereof. |