| abstract |
Benzopyran and benzoxepine compounds of Formula I and II are described, including their stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts, useful for inhibiting lipid kinase including p110 and other PI3K isoforms, and for treating such disorders. as cancer mediated by lipid kinases. Methods for using compounds of Formulas I and II for the diagnosis, prevention or treatment in vitro, in situ, and in vivo, of such disorders in mammalian cells, or associated pathological conditions. |