| abstract |
The invention is related to the new histone deacetylase inhibitors according to the general formula (I) wherein: the broken line is an optional additional bond; n is zero or an integer from 1 to 4; R1 is hydrogen; alkyl of 1 to 6 carbon atoms, optionally substituted with cycloalkyl, aryl or with heteroaryl; (CO) R3 (SO2) R4 cycloalkyl; aryl; or heteroaryl; R2 is alkyl of 1 to 6 carbon atoms, optionally substituted with aryl or with heteroaryl; aryl; heteroaryl; or (CO) R5 X is CH2, oxygen or NR6 Y is a bond, CHR7 or NR8 is oxygen, CR9R10 or C = R11 and R3, R4, R5, R6, R7, R8, R9, R10 and R11 are as defined additionally in the specification and pharmaceutically acceptable salts thereof. |