| abstract |
The invention relates to compounds of the general formula (I) in which X1, X2, X3, and X4 represent, independently of one another, a nitrogen atom or a C-R1 group W represents an oxygen or sulfur atom ; n is equal to 0, 1, 2 or 3; Y represents an aryl or an optionally substituted heteroaryl; A represents the group of the formula: (II), Z1, Z2, Z3 and Z4 represent, independently of one another, a nitrogen atom, or a group C-R2 Ra and Rb together with the carbon atoms to which they are attached, either a partially unsaturated cycloalkyl, or an aryl; either a heterocycle, or a 5- to 7-membered heteroaryl comprising from one to three heteroatoms selected from O, S or N; this cycloalkyl, this aryl, this heterocycle or this heteroaryl which may be substituted by one or more R3 substituents in the base or acid addition salt state, as well as in the hydrate or solvate state. Procedure of preparation and application in therapeutics. |