http://rdf.ncbi.nlm.nih.gov/pubchem/patent/MX-2010006182-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-501 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 |
| filingDate | 2008-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_209259f9f93ce12923b6dae8f91c4a70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e9a7fd2923c9bdbac3f262bd97957c0e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd53ce2c4146d033830f604a531158d1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_844d838a8b172d7ed06eb6f63039b53d |
| publicationDate | 2010-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | MX-2010006182-A |
| titleOfInvention | DERIVATIVES OF ISOXAZOLO-PIRIDAZINA. |
| abstract | The invention relates to compounds of the formula I (see formula (I)) in which X is O or NH; R1 is phenyl, pyridinyl, or pyrimidinyl, each of which is optionally substituted by one, two or three halogens, R2 is C1-4 alkyl, H or C1-4 haloalkyl; R3, R4 and R5 independently of each other are: H, C1-7 alkyl, optionally substituted by one or more halogen, cyano or hydroxy, C1-7 alkoxy, optionally substituted by one or more halogens, CN, halogen, NO2, - C (O) -Ra, in which Ra is hydroxy, C1-7 alkoxy, C1-7 alkyl, phenoxy or phenyl, -NRbRc, in which Rb and Rc independently of one another are: hydrogen, C1-7 alkyl, -C (O) -C 1-7 alkyl, optionally substituted by one or more halogens, -C (O) (CH 2) mO-C 1-7 alkyl, wherein m is the number 0, 1, 2, 3, 4 , 5 or 6, -C (O) C (O) O-C1-7 alkyl, -C (O) CH2C (O) O-C1-7 alkyl, -C (O) Ri, said Ri is phenyl or heteroaryl 5 or 6 members, each of them is optionally substituted by one or more E, -C (O) -C3-7cycloalkyl, optionally substituted by one or more B, -C (O) -Rii, said Rii is heterocyclyl 3 to 7 members, optionally substituted by one or more A, 3 to 7 member heterocyclyl, optionally substituted by one or more A, 5 or 6 member heteroaryl, optionally substituted by one or more E, C (O) NRdRe, in which Rd and Re independently from each other are: H, C1-7 alkyl, optionally substituted by one or more halogen, hydroxy, or cyano, - (CH2) - C3-7 cycloalkyl, optionally substituted by one or more B and t is the number 0, 1, 2, 3 or 4, - (CH2) uO-C1-7 alkyl, wherein u is the number 2, 3, 4, 5 or 6, - (CH2) x-heterocyclyl, wherein x is the number 0, 1, 2, 3 or 4, and said heterocyclyl is optionally substituted by one or more A, Rd and Re together with the nitrogen to which are attached form a heterocyclyl moiety optionally substituted by one or more A, or R3 together with the adjacent nitrogen atom of the pyridazine forms a 5-membered fused aromatic ring with two other ring nitrogen atoms, the fused ring is optionally substituted by Rf, said Rf is C1-7 alkyl, -C (O) O-C1-7 alkyl, -C (O) -C 1-7 alkyl, 5- or 6-membered heteroaryl or phenyl, each of which is optionally substituted by one or plus E, A is hydroxy, oxo, C1-7 alkyl, C1-7 alkoxy, C1-7 haloalkyl, C1-7 hydroxyalkyl, halogen or CN, B is halogen, hydroxy, CN, C1-4 alkyl or C1-4 haloalkyl , E is halogen, CN, NO 2, hydroxy, C 1-7 alkyl, C 1-7 alkoxy, C 1-7 haloalkyl, C 1-7 hydroxyalkyl, C 1-7 cyanoalkyl, C 1-7 haloalkoxy or C 3-7 cycloalkyl, or a pharmaceutically acceptable salt thereof, which have affinity and selectivity for the GABA A a5 receptor binding site, upon obtaining, to pharmaceutical compositions containing them and to the use thereof as medicaments. The active compounds of the present invention are useful as cognitive enhancers or for the treatment of cognitive disorders, for example Alzheimer's disease. |
| priorityDate | 2007-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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