| abstract |
Phonic [(imidazol-1-yl) -1-hydroxy-1-phosphono-ethyl] -phonic acids substituted by alkyl of 2 to 5 carbon atoms are described, as well as methods or processes for their manufacture, their use in manufacturing of pharmaceutical formulations, their use in the treatment of diseases, methods for use in the treatment of diseases, pharmaceutical formulations that cover them, and / or the compounds for use in the treatment of diseases. The compounds are capable of inhibiting excessive or inappropriate bone resorption, and for the treatment of other diseases that are caused by excessive precursoring of the target proteins, such as Hutchinson-Gilford progeria syndrome. The compounds are of Formula 1: (see formula (I)) wherein one of R1 and R2 is hydrogen, and the other is alkyl of 2 to 5 carbon atoms that is branched or unbranched, and which may be in form free, or in the form of an ester, and / or a salt. |