| abstract |
Anti-TENB2 antibodies produced by cysteine engineering are produced by engineering to replace one or more amino acids of a precursor anti-TENB2 antibody with uncrosslinked reactive cysteine amino acids. Methods of design, preparation, screening, and selection of anti-TENB2 antibodies produced by cysteine engineering are provided. Anti-TENB2 antibodies produced by cysteine engineering (Ab) are conjugated to one or more portions of the drug (D) through a ligation (L) to form conjugates of the drug of anti-TENB2 antibody produced by cysteine engineering that has Formula I: Ab- (LD) P where p is 1 to 4. The diagnostic and therapeutic uses for compounds and compositions are described of the antibody drug produced by cysteine engineering. |