abstract |
The present invention relates to the isoxazol-3-carboxamide derivative having the general Formula (1), or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions thereof, as well as to the use of isoxazol-3-carboxamide derivatives for the treatment of TRPV1-mediated disorders such as acute and chronic pain disorders, acute and chronic neuropathic pain, acute and chronic inflammatory pain, respiratory diseases, and lower urinary tract disorders. |