| abstract |
It is intended to provide a preventive agent or a therapeutic agent for a disease caused by abnormal bone metabolism, in particular, osteoporosis, more effective than ever. By combining the application of N-hydroxy-4- {5- [4- (5-isopropyl-2-methyl-1, 3-thiazol-4-yl) phenoxy) pentoxy} -benzamidine, or salt thereof, and one of the compounds selected from the group consisting of etidronic acid, clodronic acid, pamidronic acid, tiludronic acid, risedronic acid, minodronic acid, ibandronic acid, zoledronic acid, and salts thereof, shows an inhibitory action of bone resorption greater in compared with the administration of an individual compound, and an excellent preventive effect and therapeutic effect can be obtained for a disease caused by abnormal bone metabolism, in particular, for osteoporosis. |