| abstract |
The illustrative preferred embodiments in the present application provide formulations and methods for the delivery of drugs, particularly drugs of abuse, which have a drug of relevant abuse substantially confined in the nucleus and a drug of non-abuse relevant in a region other than the core . These formulations have a reduced potential for abuse. In the formulation, preferably the relevant abuse drug is an opioid and the relevant non-abuse drug is acetaminophen or ibuprofen. Most preferably, the opioid is hydrocodone, and the relevant non-abuse analgesic is acetaminophen. In certain preferred embodiments, dosage forms are characterized by resistance to solvent extraction; alteration, crushing or grinding. Certain embodiments of the inventions provide dosage forms that provide an initial burst of drug release followed by a prolonged period of controllable drug release. |