| abstract |
Compounds of formula II: (see figure) where R2 is the side chain of leunica, isoleucine, cyclohexylglycine, O-methyltreonine, 4-fluoroleucine or 3-methoxivaline; R3 is H, methyl or F; Rq is trifluoromethyl and Rq 'is H or Rq and Rq' defines keto; Q is a unit p- (alkyl of 1 to 6 carbonosulfonyl) phenyl atoms or a 4- (alkyl of 1 to 6 carbon atoms) piperazin-1-yl-thiazol-4-yl optionally substituted with utility in the treatment of disorders characterized by inappropriate expression or activation of cathepsin K, such as osteoporosis, ostearthritis, rheumatoid arthritis or bone metastases. |