| abstract |
(See formula (1)) The derivatives of 17ß-cyano-19-nor-androst-4-ene of the present invention possess gestagenic effectiveness. They have the general chemical formula 1, in which Z is selected from the group comprising O, two hydrogen atoms, NOR and NNHSO2R, where R is hydrogen or C1-C4-alkyl, R4 is hydrogen or halogen, in addition or: R6a , R6b together form methylene or 1,2-ethanedyl or R6a is hydrogen and R6b is selected from the group comprising hydrogen, methyl and hydroxymethylene, and R7 is selected from the group comprising hydrogen, C1-C4-alkyl, C2-C3-alkenyl and cyclopropyl, or: R6a is hydrogen and R6b and R7 together form methylene or disappear by formation of a double bond between C6 and C7., R9, R10 are hydrogen or disappear by formation of a double bond between C9 and C10, R15, R16 they are hydrogen or together form methylene, R17 is selected from the group comprising hydrogen, C1-C4-alkyl and allyl, where at least one of the substituents R4, R6a, R6b, R7, R15, R16 and R17 is not hydrogen or R6b and R7 disappear by forming a double bond between C6 and C7, and their solvates, hydrates, estere Oisomers, diastereomers, enantiomers and salts. |