http://rdf.ncbi.nlm.nih.gov/pubchem/patent/MX-2009013371-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fba5ef972720f17c5f58279c41bebdf5 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-101 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2207-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8771 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0278 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01D15-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02 |
| filingDate | 2008-06-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b701a17710d507e9ac4f0f43a02783d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5293b6635c40f8b5d5dd8921a3f442a8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_50e466a19afc862981faf0a06ced550c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_28a4af3570fb5fa2b28c3b2bf9023a2d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_06cf77d1341f169d354b6ed8388efde6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ffe9daa3ac9a2f6fd16aa64b5f15648 |
| publicationDate | 2010-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | MX-2009013371-A |
| titleOfInvention | PROCESS TO PRODUCE EXOGENA PROTEIN IN THE MILK OF TRANSGENIC MAMMALS. |
| abstract | The invention relates to a non-human transgenic mammal that is useful for the production of a protein of interest, which may be toxic to the mammal. The mammal is characterized by the fact that it is transgenic for the production in its milk of an inactive form of the protein of interest, preferably recombinant human insulin. It is not possible to produce recombinant human insulin in transgenic mammals since this molecule has a certain degree of biological activity in mammals and can be toxic to the mammal. Thus, the invention involves donating a genetic construct comprising a sequence encoding a modified human insulin precursor under the control of a beta casein promoter in an expression vector. It also involves transfecting the expression plasmid in fetal bovine somatic cells, such as fibroblasts, and enuclear bovine oocytes by nuclear transfer to generate transgenic embryos. The invention gives rise to a transgenic bovine that will be able to produce a modified human insulin precursor in its mammary glands. Subsequently, the milk of these transgenic mammals can be collected, the modified human insulin precursor can be converted in vitro into recombinant human insulin and the recombinant human insulin can be purified to. |
| priorityDate | 2007-06-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 122.