http://rdf.ncbi.nlm.nih.gov/pubchem/patent/MX-2009011642-A

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filingDate 2008-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08122ac324e249803dd88fc3a9f41e6a
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publicationDate 2010-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber MX-2009011642-A
titleOfInvention COMPOUNDS AND METHODS TO POWER THE SOLUBILITY OF FLORFENICOL AND STRUCTURALLY RELATED ANTIBIOTICS USING CYCLODEXTRINES.
abstract The relatively low solubility of florfenicol (FFC) in water (1.3 mg / ml) limits its use in medicated drinking water systems for the treatment of lung diseases of pigs and poultry; current formulations use a high volume organic solvent to reach the required FFC concentration of 13.5 mg / ml in an automated proportioning mixing tank system, with practical disadvantages for users in the field; This invention relates to the effects of complex formation with natural and modified cyclodextrins on the aqueous solubility of FFC and antibiotics of related structure; In addition, this invention relates to the effects of polyethylene glycol (PEG-300) as a cosolvent in an FFC-cyclodextrin system to achieve the required dose of FFC in the mixing tank system and avoid high volumes of the organic solvent.
priorityDate 2007-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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