| abstract |
The invention relates to compounds of formula (I) (see formula I) wherein R is selected from halogen, alkyl, alkoxy, aryl and heteroaryl; R1 is selected from 2-hydroxyethyl, 2,3-dihydroxypropyl, 3-hydroxypropyl, 2,2-dihydroxyethyl, 3,3-dihydroxypropyl, 1,3-dioxolane-ethyl, 1,3-dioxane-methyl, 1,3- dioxolane-methyl, 1,3-dioxane-ethyl, 3-fluoro-2-hydroxypropyl, 3-carboxy-2-hydroxy-propyl, 3-chloro-2-hydroxypropyl, 2-hydroxypropyl, 2-hydroxy-propen-2- yl, morpholinoethyl, piperazinoethyl, hydroxymethyl, benzyl, 4- (hydroxymethyl) benzyl, 4-chlorobenzyl, 4-fluorobenzyl and 4-hydroxybenzyl; R2 is tert-butyl or trifluoromethyl; R3 is independently selected from hydrogen, carboxy, cyano, alkyl or hydroxyalkyl; The compounds of formula (I) can be used for the preparation of pharmaceutical compositions for the therapy of inflammatory conditions, such as chronic neuropathic pain, over-active bladder syndrome, tumor pain, hemorrhoids, inflammatory hyperalgesia, post-intervention pain, extraction dental, respiratory and gastrointestinal diseases. |