| abstract |
Multiple stereoisomers of the substituted heterocyclic tricyclics of the formula are provided: (see formula) or a salt, solvate or ester acceptable for pharmaceutical use of said compound whose R and stereochemistry are illustrated in the structural formulas disclosed herein, as well as the pharmaceutical compositions containing them and a method for treating diseases related to thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, and cancer by administering said compounds; combination therapy with other cardiovascular agents is also claimed. |