| abstract |
The present invention relates to a pharmaceutical composition coated by a film comprising 5'-deoxy-5-fluoro-N - [(pentyloxy) -carbonyl] -cytidine (capecitabine) and at least one disintegrant selected from the group comprising crospovidone (particle size <15-400 µ), croscarmellose sodium, sodium starch glycolate, low substituted hydroxypropyl cellulose, Pharmaburst C or any combination thereof, together with other pharmaceutically acceptable excipients to form a rapidly disintegrating tablet. This tablet disintegrates in water at 37 ° C in a USP disintegration apparatus in less than 2 minutes, preferably 1 minute and has a hardness of 8-13 units of Cobb force. |