http://rdf.ncbi.nlm.nih.gov/pubchem/patent/MX-2009002625-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_27a71ddaaa2f5a8c228fc6cb3f3b3098 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D221-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D221-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-435 |
| filingDate | 2007-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_43cbc2852e7a503d967a0b2e3969174d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a4764ecb22cbf3aa7022ed6ee491225 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b38d960e28f234a81ab6cfdee0840b2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_627ef1925ee8dfed3b4bf94951eaf81a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6302b7bf4bd9c5e1490cb590114d2943 |
| publicationDate | 2009-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | MX-2009002625-A |
| titleOfInvention | AZABICICLIC COMPOUNDS AS INHIBITORS OF RECOVERY OF MONOAMINS. |
| abstract | The present invention relates to new compounds of formula (I) ', pharmaceutically acceptable salts, prodrugs or solvates thereof: (see formula (I)') where: R 1 is hydrogen or C 1-4 alkyl; R2 is a group A, K or W where: A is (see formula); K is an a or β-naphthyl group, optionally substituted with 1 or 2 R18 groups, each being the same or different; and W is (see formula) and where G is a 5- or 6-membered monocyclic heteroaryl group or an 8 to 11-membered bicyclic heteroaryl group; such that G may be substituted with (R15) p, which may be the same or different; p is an integer between 0 and 5; R3 is selected from the group consisting of: hydrogen, fluorine and C1-4 alkyl; or corresponds to a group X or X1; R4 is selected from the group consisting of: hydrogen, fluorine and C1-4 alkyl, or corresponds to a group X or X1; R5 is hydrogen or C1-4 alkyl; R7 is hydrogen or C1-4 alkyl; or is a group X, X1, X2 or X3; where: X is (see formula) X1 is (see formula) X2 is (see formula) and X3 is (see formula) R6 is hydrogen or C1-4 alkyl; or is a group X or X1; R9 is C1-4 alkyl; R10 is selected from a group consisting of: hydrogen, halogen, hydroxy, cyano, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy C1-4 alkanoyl and SF5; or corresponds to a group R8; R8 is a 5-6 membered heterocycle group, which may be substituted with one or two substituents selected from a group consisting of: halogen, cyano C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy and C1-4 alkanoyl ; R11 is selected from a group consisting of: hydrogen, halogen, hydroxy, cyano, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, C1-4 alkanoyl and SF5; or corresponds to a group R8; R12 is selected from a group consisting of: hydrogen, halogen, hydroxy, cyano, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, C1-4 alkanoyl and SF5; or corresponds to a group R8; R13 is selected from a group consisting of: hydrogen, halogen, hydroxy, cyano, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy C1-4 haloalkoxy, C1-4 alkanoyl and SF5; or corresponds to a group R8; R14 is selected from a group consisting of: hydrogen, halogen, hydroxy, cyano, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy. C1-4 alkanoyl and SF5; or corresponds to a group R8; R15 is selected from a group consisting of: halogen, hydroxy, cyano, C1-4 alkyl. C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, C1-4 alkanoyl and SF5; or corresponds to a group R8; R16 is hydrogen, C1-4 alkyl, C3-6 cycloalkyl or C3-6 cycloalkyl-C1-3 alkyl; R17 is hydrogen or C1-4 alkyl; R18 is selected from a group consisting of: halogen, cyano, C1-4 alkyl; R19 is C1-2 haloalkyl; n is 1 or 2; with the proviso that: if R2 is A, R3, R4, R5, R6, R7, R10, R11, R13 and R14 are hydrogen and R12 is fluorine, R1 is C1-4 alkyl; if R2 is A, R3, R4, R5, R6, R7, R10, R11, R13 and R14 are hydrogen and R1 is methyl, R12 is halogen, hydroxy, cyano, C1-4 alkyl, C1-4 haloalkyl, C1- alkoxy 4, C1-4 haloalkoxy, C1-4 alkanoyl and SF5; or corresponds to an R8 group; to processes for their preparation, to intermediates used in these processes, to pharmaceutical compositions containing them and to their use in therapy, such as serotonin (5-HT), dopamine (DA) and norepinephrine (NE) reuptake inhibitors. |
| priorityDate | 2006-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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