| abstract |
The compound (I) in which R is a heterocyclic radical; R1 and R2 are independently H or alkyl; R3 is H, alkyl. cycloalkyl, cycloalkylalkyl, alkenyl, aryl, arylalkyl, heterocyclic or heterocyclylalkyl; R4 and R5 are independently H or alkyl; q is a number selected between 0 and 1; and its salts, solvates, prodrugs or stereoisomers have inhibitory activity of UBC13-UEV interactions and can be used in the elaboration of pharmaceutical compositions directed to antitumor therapy or to the treatment and / or prophylaxis of diseases associated with metabolic pathways in which it intervenes. the UB13 enzyme, metabolic pathways in which the transcriptional factor NF-B is involved, or routes in which PCNA or RDA6 are involved. R- (CR1R2) q-CO-N (R3) -C (R4R5) -CO-NH2. |